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Séminaire « Matière molle : organisation et dynamique » de l’INSP

« Shape changes of cell-sized liposomes reveal actomyosin forces » - Cécile Sykes - Lundi 15 juin 2015 à 11 h

INSP - 4 place Jussieu - 75252 PARIS Cedex 05 - Barre 22-32 - 2e étage, salle 201

Cécile Sykes - Laboratoire Physicochimie Curie

Abstract

In order to unveil generic mechanisms of cell movements and shape changes, we design stripped-down experimental systems that reproduce cellular behaviours in simplified conditions, using liposome membranes on which cytoskeleton dynamics are reconstituted. Such stripped-down systems allow for a controlled study of the physical mechanisms that underlie cell movements and cell shape changes. Moreover, these experimental systems are used to address biological issues within a controlled, simplified environment. We have reconstituted the actin cortex of cells at the membrane of liposomes, and characterized their mechanical properties. We will show how these cortices contract in the presence of myosin motors, and how such experiments shed light of the mechanisms of cell shape changes.